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SAHA has also been found to be neuroprotective in dopaminergic neurons from midbrain primary culture by induction of neurotrophic factors from astroglia through induction of histone acetylation (Jung et al., 2008) have reported VPA to stimulate differentiation and reduce proliferation in rat cerebral cortex neural progenitor cells via the activation of ERK-P21 Cip/WAFI pathway

Additionally, the peptide is observed to interact with the Focal Adhesion Kinase (FAK)-paxillin pathway, potentially influencing fibroblast migration during tissue remodeling

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Twice-weekly sessions during the first month tend to accelerate early progress